Abstract
BackgroundObesity is a health problem that is reaching epidemic proportions worldwide. We investigated the effects of a life-long high saturated fat and low carbohydrate (HF) diet on the body mass, glucose tolerance, cognitive performance and lifespan of mice.FindingsC57BL/6J mice were fed with a HF diet (60% kcal/fat) or control diets (15% kcal/fat) for 27 months. One-half of the mice on the HF diet developed obesity (diet-induced obese (DIO) mice), whereas the remaining mice were diet resistant (DR). At 8 months of age, both DIO and DR groups had increased hyperglycemic response during a glucose tolerance test, which was normalized in 16-month-old mice. At this latter time point, all groups presented similar performance in cognitive tests (Morris water maze and inhibitory avoidance). The survival curves of the HF and control diet groups started to diverge at 15 months of age and, after 27 months, the survival rate of mice in the DIO and DR groups was 40%, whereas in the control diet group it was 75%.ConclusionsAHFdiet decreased the survival of mice independent of bodyweight.
Highlights
Obesity is a health problem that is reaching epidemic proportions worldwide
AHFdiet decreased the survival of mice independent of bodyweight
High-fat diet decreases survival Obesity and overweight are associated with numerous co-morbidities, including type 2 diabetes and neuropsychiatric disorders [1,2,3]
Summary
High-fat diet decreases survival Obesity and overweight are associated with numerous co-morbidities, including type 2 diabetes and neuropsychiatric disorders [1,2,3]. A sedentary lifestyle and excessive consumption of diets enriched in saturated fat and/or high glucose contribute to the onset and progression of these co-morbidities [4,5] leading to decreased life expectancy [6,7]. The effects of increased ingestion of dietary fat and carbohydrate are well stabilized in rodent models, leading to obesity and disturbed glucose metabolism, similar to that seen in humans [8,9,10]. We aimed to identify changes associated with consumption of alife-long high saturated fat and low carbohydrate (HF) diet on glucose tolerance, memory performance and life expectancy in C57BL/6 mice, comparing those mice that developed obesity (diet-induced obesity, DIO) to those that were resistant to obesity (diet resistant; DR)
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