Abstract
Summary This study compared the diagnostic accuracy of highresolution and standard-resolution cardiovascular magnetic resonance (CMR) perfusion imaging in patients with suspected coronary artery disease (CAD). Background Although accelerated high-spatial-resolution CMR perfusion imaging has recently been shown to be clinically feasible, there has not yet been a direct comparison with standard-resolution methods. We hypothesised that higher spatial resolution detects more subendocardial ischemia and leads to greater diagnostic accuracy for the detection of angiographically defined CAD. Methods A total of 111 patients with suspected CAD were prospectively recruited. All patients underwent two separate perfusion CMR studies on a 1.5 Tesla CMR scanner (Intera CV, Philips Healthcare, Best, the Netherlands), one with standard-resolution (2.5 x 2.5mm in-plane resolution) and one with high-resolution (1.6 x 1.6mm in-plane resolution) acquisition. High-resolution acquisition was facilitated by eight-fold k-t broad linear speed up technique (BLAST) acceleration. Two observers visually graded perfusion in each myocardial segment on a 4-point scale. Segmental scores were summed to produce a perfusion score for each patient. All patients underwent invasive coronary angiography. Significant CAD was defined as a coronary artery stenosis of ≥ 50% diameter on quantitative coronary angiography. Results CMR data were successfully obtained in 100 patients. A typical example is shown in Figure 1. In patients with CAD (n=70), more segments were determined to have subendocardial ischemia with high-resolution acquisition than with standard-resolution acquisition (279 vs.108; p<0.001). High-resolution acquisition had a greater diagnostic accuracy than standard-resolution acquisition for identifying single-vessel disease (area under the curve [AUC]: 0.88 vs. 0.73; p<0.001) or multi-vessel disease (AUC: 0.98 vs. 0.91; p=0.002) and overall (AUC: 0.93 vs. 0.83; p<0.001) (Figure 2). Conclusions Our study shows that high-resolution CMR perfusion imaging has greater diagnostic accuracy than standardresolution acquisition for the detection of CAD in both single and multi-vessel disease and detects more subendocardial ischemia. Funding
Highlights
Accelerated high-spatial-resolution cardiovascular magnetic resonance (CMR) perfusion imaging has recently been shown to be clinically feasible, there has not yet been a direct comparison with standard-resolution methods
Summary This study compared the diagnostic accuracy of highresolution and standard-resolution cardiovascular magnetic resonance (CMR) perfusion imaging in patients with suspected coronary artery disease (CAD)
We hypothesised that higher spatial resolution detects more subendocardial ischemia and leads to greater diagnostic accuracy for the detection of angiographically defined CAD
Summary
Manish Motwani1*, Neil Maredia, Timothy Fairbairn, Sebastian Kozerke, Aleksandra Radjenovic, John P Greenwood, Sven Plein. Summary This study compared the diagnostic accuracy of highresolution and standard-resolution cardiovascular magnetic resonance (CMR) perfusion imaging in patients with suspected coronary artery disease (CAD)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have