Abstract
On average 100,000 persons are bitten by venomous snakes in China each year, with a mortality rate of 5 – 10% [1]. Gloydius blomhoffi brevicaudus, Deinagkistrodon acutus, Naja naja atra and Trimeresurus stejnegeri bites are most common. Necrotizing enzymes phospholipase A2, proteases, and hyaluronidase in the snake venom cause local tissue damage. Clausena excavata is a common plant used against snakebite in China. The aim of our study was to explore the anti-necrosis potential of plant C. excavata and identify non-tannin anti-necrosis constituents.
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