Abstract
The unusual conformational behaviour of a series of new cyclodextrin (CD) dimers is studied by dedicated 1H-NMR techniques. In water some CD-dimers form stable self-inclusion complexes, for which the aliphatic linker is partially included in one of the two CD cavities. This phenomenon affects the conformation of the substituted sugar ring of one CD moiety. In the case of the α-β heterodimer, the linker appears to be preferentially in the cavity of β-CD, in contrast to what is known for intermolecular complexes where at ambient temperature a preference for α-CD is observed.
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