High prevalence of anti-neuronal antibodies in Tunisian psychiatric inpatients.

Abstract

Event Abstract Back to Event High prevalence of anti-neuronal antibodies in Tunisian psychiatric inpatients. Lilia Laadhar1*, Oussama Sidhom2, Mondher Zitouni1, Nadia Sassi1, Maryam Kallel-Sellami1, Zouheir Elhechimi2 and Sondes Makni1 1 Immunology Department, La rabta hospital, Tunisia 2 Razi hospital, Psychiatry F, Tunisia Purpose: Antineuronal autoantibodies are associated with paraneoplastic syndrome. They may target nuclear or cytoplasmic antigens. We aimed in this study to determine the prevalence of anti-neuronal antibodies in Tunisian psychiatric inpatients. Subjects and methods: We enrolled in this prospective study, 103 psychiatric inpatients and 41 healthy, age and sex matched blood donors. Patients and controls had no history of malignancies or neurological disorders. For all subjects, we performed indirect imunofluorescence on primate cerebellum sections. Positive sera by immunofluorescence were also tested by an immonoenzymatic test combining a western blot of primate cerebellum extract and recombinant antigens. Results: Using indirect immunofluorescence, antineuronal nuclear autoantibodies were detected in 17 patients and none of controls (p=0.003) and antibodies reacting with cytoplasm of Purkinje cells in 6 patients and 2 controls. There was no difference of the prevalence of autoantibodies across the 4 groups of patients.The immunoblot confirmed well-characterized antineuronal antibodies only in 5 patients: two had anti-Ri (1 man and 1 woman with schizophrenia) and 3 had anti-Yo antibodies (3 men, 2 with bipolar disorder and 1 with schizophrenia). After a mean follow-up of 5 years, none of these patients developed neurological disorder or malignancy. Conclusion: In our knowledge, our study is the first one assessing the prevalence of antineuronal antibodies in psychiatric patients. The high prevalence of these antibodies in our patients may highlight the possible contribution of neuronal autoantigens in the physiopathology of some psychiatric disorders. Further studies on a larger cohort are needed to confirm this hypothesis. Keywords: Autoantibodies, antineuronal, Psychiatry, Schizophrenia, prognosis Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Immune-mediated disease pathogenesis Citation: Laadhar L, Sidhom O, Zitouni M, Sassi N, Kallel-Sellami M, Elhechimi Z and Makni S (2013). High prevalence of anti-neuronal antibodies in Tunisian psychiatric inpatients.. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00243 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 12 Mar 2013; Published Online: 22 Aug 2013. * Correspondence: Dr. Lilia Laadhar, Immunology Department, La rabta hospital, Tunis, Tunisia, lilia_laadhar@yahoo.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Lilia Laadhar Oussama Sidhom Mondher Zitouni Nadia Sassi Maryam Kallel-Sellami Zouheir Elhechimi Sondes Makni Google Lilia Laadhar Oussama Sidhom Mondher Zitouni Nadia Sassi Maryam Kallel-Sellami Zouheir Elhechimi Sondes Makni Google Scholar Lilia Laadhar Oussama Sidhom Mondher Zitouni Nadia Sassi Maryam Kallel-Sellami Zouheir Elhechimi Sondes Makni PubMed Lilia Laadhar Oussama Sidhom Mondher Zitouni Nadia Sassi Maryam Kallel-Sellami Zouheir Elhechimi Sondes Makni Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.