Usefulness of pituitary antibodies in the management of non-tumoral pituitary diseases in Tunisian adults

Abstract

Event Abstract Back to Event Usefulness of pituitary antibodies in the management of non-tumoral pituitary diseases in Tunisian adults Lilia Laadhar1*, Malika Chihaoui2, Maryam Kallel-Sellami1, Nadia Sassi1, Bochra Ftouhi2, Houria Lahmar1, Faouzi Kanoun2, Hedia Slimane2 and Sondes Makni1 1 Immunology Department, La rabta hospital, Tunisia 2 La Rabta hospital, Endocrinology, Tunisia Purpose: Pituitary antibodies (PAs) are directed against cells of the anterior and the posterior lobes of the pituitary gland. The aim of our study was to assess the usefulness of PAs in the management of non-tumoral pituitary diseases in Tunisian adults. Subjects and methods: In this prospective study, we recruited 43 cases of non-tumoral pituitary pathologies. PAs were detected by indirect immunofluoresence on monkey pituitary gland. Results: Patients were 41 women and 2 men, mean age 43.5 ± 12.8 years. APs were positive in 12 patients (28%), 4 APs were directed against the anterior lobe and 10 against the posterior lobe of pituitary gland (2 patients had APs against anterior and posterior lobe at the same time). Twenty one women had a postpartum hypopituitarism suggestive of a Sheehan syndrome, 7 among them had PAs. Fifteen patients had a hypopituitarism without Sheehan syndrome and without malignancy (according to the MRI of the pituitary gland), 3 of them were APs positive. Seven patients had autoimmune polyendocrinopathy and only 3 of them had hypopituitarism. In this last group APs were positive in 4 cases. APs were more frequently detected in patients with autoimmune polyendocrinopathy than others but the difference was not statistically significant. Conclusion: Despite the low number of our patients, we reported a high prevalence of APs in non-tumoral pituitary diseases even in a context of a non autoimmune hypophysitis confirming the poor specificity of these antibodies. Additional studies are needed to identify more reliable marker for the diagnosis of lymphocytic hypophysitis. Keywords: Autoantibodies, Pituitary Gland, lymphocytic hypophysitis, Hypopituitarism, diagnostic Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Immune-mediated disease pathogenesis Citation: Laadhar L, Chihaoui M, Kallel-Sellami M, Sassi N, Ftouhi B, Lahmar H, Kanoun F, Slimane H and Makni S (2013). Usefulness of pituitary antibodies in the management of non-tumoral pituitary diseases in Tunisian adults. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00265 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 12 Mar 2013; Published Online: 22 Aug 2013. * Correspondence: Dr. Lilia Laadhar, Immunology Department, La rabta hospital, Tunis, Tunisia, lilia_laadhar@yahoo.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Lilia Laadhar Malika Chihaoui Maryam Kallel-Sellami Nadia Sassi Bochra Ftouhi Houria Lahmar Faouzi Kanoun Hedia Slimane Sondes Makni Google Lilia Laadhar Malika Chihaoui Maryam Kallel-Sellami Nadia Sassi Bochra Ftouhi Houria Lahmar Faouzi Kanoun Hedia Slimane Sondes Makni Google Scholar Lilia Laadhar Malika Chihaoui Maryam Kallel-Sellami Nadia Sassi Bochra Ftouhi Houria Lahmar Faouzi Kanoun Hedia Slimane Sondes Makni PubMed Lilia Laadhar Malika Chihaoui Maryam Kallel-Sellami Nadia Sassi Bochra Ftouhi Houria Lahmar Faouzi Kanoun Hedia Slimane Sondes Makni Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.