Abstract

Address: 1Dept of Neonatology, University of Bonn, Sigmund Freud Strasse 25, D-53105 Bonn, Germany, 2Dept of Neonatology, Charite, Campus Virchow, Klinikum Universitatsmedizin Berlin, Augustenburger Platz 1, D-13353 Berlin, Germany, 3Dept of Pediatrics, University Medical Center, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, the Netherlands, 4Dept of Neurosurgery, University Medical Center, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, the Netherlands, 5Dept of Pediatric Neurology, University Medical Center, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, the Netherlands and 6Dept of Neurosurgery, University of Bonn, Sigmund Freud Strasse 25, D53105 Bonn, Germany

Highlights

  • High pressure hydrocephalus (HC) is associated with micro-glial activation and subsequent white matter damage

  • Under various pathological conditions, increased CSF interleukin-18 (IL-18; expressed in microglial cells) and interferon gamma (IFNg; expressed in natural killer cells affecting oligodendrocytes) concentrations relate with white matter damage

  • We hypothesize that CSF IL-18 and IFNg concentrations are increased in neonatal high pressure HC, irrespective of underlying etiology

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Summary

Open Access

Address: 1Dept of Neonatology, University of Bonn, Sigmund Freud Strasse 25, D-53105 Bonn, Germany, 2Dept of Neonatology, Charité, Campus Virchow, Klinikum Universitätsmedizin Berlin, Augustenburger Platz 1, D-13353 Berlin, Germany, 3Dept of Pediatrics, University Medical Center, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, the Netherlands, 4Dept of Neurosurgery, University Medical Center, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, the Netherlands, 5Dept of Pediatric Neurology, University Medical Center, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, the Netherlands and 6Dept of Neurosurgery, University of Bonn, Sigmund Freud Strasse 25, D53105 Bonn, Germany. Published: 20 December 2007 Cerebrospinal Fluid Research 2007, 4(Suppl 1):S48 doi:10.1186/1743-8454-4-S1-S48. 51st Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/files/pdf/1743-8454-4-S1-info.pdf

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