Abstract
article i nfo Background:In the present study, we evaluated the association of platelet reactivity with vascular function in pa- tients after percutaneous coronary intervention receiving clopidogrel treatment. Methods:Weenrolled 150 patients with stableCADreceiving clopidogrelregimen (75 mg/d), 1 month after per- cutaneouscoronaryintervention.Carotid-femoral pulse wave velocity (PWV)wasmeasuredasanindexofaortic stiffness and augmentation index (AIx) as an index of arterial wave reflections. High on treatment platelet reac- tivity (HPR) was evaluated using VerifyNow Assay. VerifyNow reports its results in P2Y12 reaction units (PRU), and the diagnostic cutoff value is 230 PRU. Patients were evaluated prospectively up to 24 months. The primary end point was a composite of death from cardiovascular causes, nonfatal major cardiovascular events and hospi-
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