Abstract
Aim: Adenoviruses are the most efficient vectors in preclinical and clinical trials. We previously reported differences in transgene expression after systemic adenoviral VEGF-A gene transfer in hyperlipidemic mouse models. The aim of this study was to find out whether high lipid levels and specific lipoproteins could decrease adenoviral transduction efficiency and potentially relate to insufficient transgene expression after adenoviral gene transfer in clinical trials.
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