Abstract
Polyelectrolyte-coated nanoparticles consisting of terbium and gadolinium complexes with calix[4]arene tetra-diketone ligand were first synthesized. The antenna effect of the ligand on Tb(III) green luminescence and the presence of water molecules in the coordination sphere of Gd(III) bring strong luminescent and magnetic performance to the core-shell nanoparticles. The size and the core-shell morphology of the colloids were studied using transmission electron microscopy and dynamic light scattering. The correlation between photophysical and magnetic properties of the nanoparticles and their core composition was highlighted. The core composition was optimized for the longitudinal relaxivity to be greater than that of the commercial magnetic resonance imaging (MRI) contrast agents together with high level of Tb(III)-centered luminescence. The tuning of both magnetic and luminescent output of nanoparticles is obtained via the simple variation of lanthanide chelates concentrations in the initial synthetic solution. The exposure of the pheochromocytoma 12 (PC 12) tumor cells and periphery human blood lymphocytes to nanoparticles results in negligible effect on cell viability, decreased platelet aggregation and bright coloring, indicating the nanoparticles as promising candidates for dual magneto-fluorescent bioimaging.
Highlights
Having seven unpaired electrons at the valence shell, gadolinium in the form of chelates provides high positive contrast between healthy and tumor tissues[14]
Gadolinium(III) complexes with calix[4]arene tetra-diketone ligand 1 (Fig. 1) according to the procedure described in the experimental section
Transmission electron microscopy (TEM) and dynamic light scattering (DLS) techniques were applied to examine the morphology of the fabricated colloids
Summary
Having seven unpaired electrons at the valence shell, gadolinium in the form of chelates provides high positive contrast between healthy and tumor tissues[14]. Novel MRI CA based on gadolinium-containing nanoparticles show enhanced relaxation parameters compared to commercial specimens[13,23,24,25,26]. The new nanoparticles are rationally designed to simultaneously exhibit the optical properties of Tb and the magnetic behavior of Gd ions, towards bifunctional system with strong luminescence and high relaxivity. Particular attention was paid to the simplicity and universality of the strategy for the synthesis of bifunctional species Tuning both magnetic and luminescent output of nanoparticles is possible via simple variation of composition of initial synthetic solution of lanthanides chelates. This synthetic strategy opens the door to new biomedical applications of lanthanide complexes
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
