Abstract
The purpose of this study is to establish the minimal injection doses of magnetic resonance imaging (MRI) contrast agents that can achieve optimized images while improving the safety of injectable MRI drugs. Gadolinium-diethylenetriamine penta-acetic acid (Gd-DTPA) and ferucarbotran, commonly used in clinical practice, were selected and evaluated with in vitro and in vivo experiments. MRI was acquired using T1-weighted (T1W) and T2-weighted (T2W) sequences, and the results were quantitatively analyzed. For in vitro experiments, results showed that T1W and T2W images were optimal when Gd-DTPA-bisamide (2-oxoethyl) (Gd-DTPA-BMEA) and ferucarbotran were diluted to a volume percentage of 0.6% and 0.05%; all comparisons were significant differences in grayscale statistics using one-way analysis of variance (ANOVA). For in vivo experiments, the contrast agent with optimal concentration percentages determined from in vitro experiments were injected into mice with an injection volume of 100 μL, and the images of brain, heart, liver, and mesentery before and after injection were compared. The statistical results showed that the p values of both T1W and T2W were less than 0.001, which were statistically significant. Under safety considerations for MRI contrast agent injection, optimized MRI images could still be obtained after reducing the injection concentration, which can provide a reference for the safety concentrations of MRI contrast agent injection in the future.
Highlights
Magnetic resonance imaging (MRI) was developed in 1973 for application to medical diagnosis; it since has become an indispensable technology [1,2,3,4,5,6,7]
T2W pulse sequence D.D. water sample imaging, it could be clearly distinguished from the MRI Digital Imaging and Communications in Medicine (DICOM) grayscale image that T1W presented low signal images and T2W presented high signal images
The results indicate that the image contrast of iron oxide is superior to Gadolinium-diethylenetriamine penta-acetic acid (Gd-DTPA)-BMEA, and iron oxide is suitable for the liver, and applicable to other organs and tissues [33,34,35,36]
Summary
Magnetic resonance imaging (MRI) was developed in 1973 for application to medical diagnosis; it since has become an indispensable technology [1,2,3,4,5,6,7]. According to the basis of imaging, the magnetic momentum generated by the spinning of hydrogen protons in organisms, when placed in an applied external static magnetic field, causes them to move longitudinally towards the direction of the static magnetic field and be arranged in a consistent direction with the magnetic field. At this time, when a radio frequency (RF). The magnetic moment of protons will slowly return to the static magnetic field or longitudinal motion direction in the balanced state This action is called longitudinal or spin lattice relaxation time. After the released energy is received by the receiver coil, and the signals are converted by the terminal, they will present different grayscale images [8]
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