Abstract
Synthetic chromones and isoflavones have been investigated by high-performance reversed-phase partition chromatography on C 8 and C 18 stationary phases in the isocratic mode, using methanol—water and acetonitrile—water eluents. The effect of various substituents on the retention time and capacity ratio was studied. It has been shown that methyl and methoxyl groups increase, whereas a hydroxyl substituent decreases the value of retention time. The effects of these groups on the retention time and on the degree of separation can be predicted for chromones. Of the other substituents the 2-trifluoromethyl, 6-chloro and cyclic groups ( e.g. phenyl, benzyl, thiazolyl etc.) increased the retention time while the opposite effect was observed in the case of certain nitrogen-containing (tetrazolyl, cyano, carboxamido) functions.
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