Abstract
An HPLC method for analysis of the enantiomers of the antimalarial drug mefloquine is presented. A complete resolution of (−)-(11 S,2′ R) and (+)-(11 R,2′ S) erythro-mefloquine from plasma and urine was obtained on a commercial AGP column. Mefloquine enantiomers were detected by UV at 222 nm. The separation factor (α) at + 20°C was 1.50. The limit of determination (coefficient of variation 4.0%) for the enantiomeric ratio (11 S,2′ R)/(11 R,2′ S) is 15:1 at a total mefloquine concentration of 1.6 m M.
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Schedule a callMore From: Journal of Chromatography B: Biomedical Sciences and Applications
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