High lipoprotein(a) and systemic inflammation jointly confer additive high risk of atherosclerotic cardiovascular disease and aortic valve stenosis

P.E Thomas,S.V Krogh,P.R Kamstrup,B.G Nordestgaard

doi:10.1016/j.atherosclerosis.2022.06.010

High lipoprotein(a) and systemic inflammation jointly confer additive high risk of atherosclerotic cardiovascular disease and aortic valve stenosis

P.E Thomas, S.V Krogh + Show 2 more

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https://doi.org/10.1016/j.atherosclerosis.2022.06.010

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Journal: Atherosclerosis

Publication Date: Aug 1, 2022

Affiliation: Gentofte Hospital, University of Copenhagen

#Low-grade Systemic Inflammation #Atherosclerotic Cardiovascular Disease + Show 8 more

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Abstract

Background and Aims : Lipoprotein(a) and low-grade systemic inflammation are both risk factors for atherosclerotic cardiovascular disease (ASCVD) but recent evidence has indicated that the lipoprotein(a)-associated ASCVD risk is observed only in individuals with low-grade systemic inflammation. We hypothesized that high lipoprotein(a) and low-grade systemic inflammation, measured as high sensitive C-reactive protein (hsCRP), jointly influence the risk of ASCVD and aortic valve stenosis (AVS).

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