High levels of soluble endoglin induce inflammation and oxidative stress in aorta compensated with preserved no-dependent vasodilatation mice fed high fat diet

Abstract

Objectives: A soluble form of endoglin (sEng) is generated by the cleavage of its extracellular domain during development of some pathological conditions. Moreover, several authors have suggested the participation of sEng in the mechanisms of endothelial dysfunction. Thus, we tested the hypothesis that high plasma concentration of sEng in Sol-Eng+ mice combined with high fat diet might contribute to the development of endothelial dysfunction.