Abstract
Purpose: To evaluate the effects of male aging on semen quality and DNA fragmentation in male infertility patients attending Andrology Laboratory at fertility center. Methods: Semen samples of 217 infertile patients were analyzed using Computer-Assisted Semen Analysis (CASA). Sperm DNA fragmentation was measured by the sperm chromatin dispersion test. Results: Subject’s ages ranged from 21 to 68 years. The mean age was 38.45 years. The patients were distributed into four groups: <30 years, 30-39 years, 40-49 years and ≥ 50 years. Parameters of volume, pH and concentration were similar in four evaluated groups (P: NS). An age-dependent increase in sperm DNA fragmentation was observed in four evaluated groups. The patients ≥ 40 years old had spermatozoa with fragmented DNA significantly higher compared to those patients from <30 years old and 30-39 years old (P<0.05). Percentages of morphologically normal spermatozoa in patients of ≥ 50 years old were significantly lower compared to those men from group 30-39 years old (P<0.05). Men older than 40 years old had percentages of sperm vitality significantly lower compared to men of 39 years old or less (P<0.05). Conclusions: Sperm DNA fragmentation, progressive motility, and spermatozoa morphology are associated to advanced paternal age. However, volume, pH, and sperm concentration are not affected by male age.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
