Abstract

Kinesins play important roles in the progression and development of cancer. Kinesin family member C1 (KIFC1), a minus end-directed motor protein, is a novel Kinesin involved in the clustering of excess centrosomes found in cancer cells. Recently KIFC1 has shown to play a role in the progression of many different cancers, however, the involvement of KIFC1 in the progression of prostate cancer (PCa) is still not well understood. This study investigated the expression and clinical significance of KIFC1 in PCa by utilizing multiple publicly available datasets to analyze KIFC1 expression in patient samples. High KIFC1 expression was found to be associated with high Gleason score, high tumor stage, metastatic lesions, high ploidy levels, and lower recurrence-free survival. These results reveal that high KIFC1 levels are associated with a poor prognosis for PCa patients and could act as a prognostic indicator for PCa patients as well.

Highlights

  • Prostate cancer (PCa) is the most commonly diagnosed cancer in men worldwide and the second leading cause of cancer deaths in American men [8]

  • We demonstrate that high Kinesin family member C1 (KIFC1) expression is associated with high grade, high stage, high ploidy, and metastatic PCa

  • High KIFC1 levels are associated with higher Gleason score

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Summary

Introduction

Prostate cancer (PCa) is the most commonly diagnosed cancer (aside from non-melanoma skin cancer) in men worldwide and the second leading cause of cancer deaths in American men [8]. Cancer cells can undergo endoreplication, failed cytokinesis, or fusion which generates excess centrosomes within the cell. These same mechanisms generate higher levels of genomic content in cancer cells taking cancer cells from aneuploid to polyploid or polyaneuploid [11]. The correct distribution of centrosome number is critical for normal functioning of centrosome signaling and normal cell division [20]. Multipolarity is normally lethal but cells are able to avoid death by clustering their centrosomes and inducing bi-polar division

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