Abstract
Movement related synchronization of high frequency activity (HFA, 76–100 Hz) is a somatotopic process with spectral power changes occurring during movement in the sensorimotor cortex (Miller et al., 2007) [1]. These features allowed movement-related changes in HFA to be used to functionally validate the estimations of subdural electrode locations, which may be placed temporarily for research in deep brain stimulation surgery, using the novel tool described in Randazzo et al. (2015) [2]. We recorded electrocorticography (ECoG) signals and localized electrodes in the region of the sensorimotor cortex during an externally cued hand grip task in 8 subjects. Movement related HFA was determined for each trial by comparing HFA spectral power during movement epochs to pre-movement baseline epochs. Significant movement related HFA was found to be focal in time and space, occurring only during movement and only in a subset of electrodes localized to the pre- and post-central gyri near the hand knob. To further demonstrate the use of movement related HFA to aid electrode localization, we provide a sample of the electrode localization tool, with data loaded to allow readers to map movement related HFA onto the cortical surface of a sample patient.
Highlights
Xlsx of analyzed data and pivot table, Matlab software package Human subjects underwent ECoG recordings while squeezing grip force transducers in an externally cued, bilateral hand grip task Activation weight in the high frequency band (70–100 Hz) were calculated from power spectra of ECoG signals during 500 ms epochs before, during and after contralateral hand UPMC Presbyterian Hospital, Dept. of Neurological Surgery, Brain Modulation Laboratory Data are available in accompanying.zip folder, and the localizer sample software package will be maintained on our lab website
Following Go Cues, subjects successfully completed the trial if they responded with the correct hand only in o2 s and maintained at least 10% of their previously measured maximum voluntary grip force for at least 100 ms
The software package comes with the HFA data for this sample patient pre-loaded and is equipped to map this data onto the cortical surface based upon the electrode localization
Summary
Movement related synchronization of high frequency activity (HFA, 76–100 Hz) is a somatotopic process with spectral power changes occurring during movement in the sensorimotor cortex (Miller et al, 2007) [1]. These features allowed movementrelated changes in HFA to be used to functionally validate the estimations of subdural electrode locations, which may be placed temporarily for research in deep brain stimulation surgery, using the novel tool described in Randazzo et al (2015) [2]. & 2015 Elsevier Inc. Published by Elsevier Inc. Published by Elsevier Inc
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