High-dose dual-antibiotic loaded bone cement in patients undergoing hemiarthroplasty

Abstract

Hip fractures continue to be a major cause of morbidity and mortality in the older population. 1 Moran CG Wenn RT Sikand M Taylor AM Early mortality after hip fracture: is delay before surgery important?. J Bone Joint Surg Am. 2005; 87: 483-489 Crossref PubMed Scopus (546) Google Scholar Furthermore, due to substantial improvements in life expectancy worldwide, the annual number of patients with hip fracture is expected to reach an all-time high over the course of the next two decades. 2 Cooper C Campion G Melton 3rd, LJ Hip fractures in the elderly: a world-wide projection. Osteoporos Int. 1992; 2: 285-289 Crossref PubMed Scopus (2406) Google Scholar Although there is currently no gold standard for the surgical management of patients with hip fractures, hemiarthroplasty continues to be one of the more popular treatment options in these patients. 3 Bhandari M Einhorn T A Guyatt G et al. Total hip arthroplasty or hemiarthroplasty for hip fracture. N Engl J Med. 2019; 381: 2199-2208 Crossref PubMed Scopus (178) Google Scholar Concurrently, surgical site infection (SSI) is a devastating complication following hemiarthroplasty, and one of the leading causes of mortality and morbidity in these patients. 4 Gupta A Shin J Oliver D Vives M Lin S Incidence and risk factors for surgical site infection (SSI) after primary hip hemiarthroplasty: an analysis of the ACS-NSQIP hip fracture procedure targeted database. Arthroplasty. 2023; 5: 1-7 Crossref PubMed Scopus (0) Google Scholar High-dose dual-antibiotic loaded cement for hip hemiarthroplasty in the UK (WHiTE 8): a randomised controlled trialIn this trial, the use of high-dose dual-antibiotic loaded cement did not reduce the rate of deep surgical site deep infection among people aged 60 years or older receiving a hemiarthroplasty for intracapsular fracture of the hip. Full-Text PDF Open Access