High-density lipoprotein cholesterol and risk of cardiovascular events in octogenarian patients with acute coronary syndrome: Long-term follow-up study

Abstract

Acute coronary syndromes (ACS) represents serious clinical types of coronary heart disease (CHD), which accounts for 35% of all deaths among persons more than 65 years of age [ [1] Kochanek K.D. Smith B.L. Deaths: preliminary data for 2002. Natl Vital Stat Rep. 2004; 52: 1-47 PubMed Google Scholar ]. Several studies show that low HDL-C is associated with residual risk of cardiovascular long-term outcomes [ 2 Di Angelantonio E. Sarwar N. Perry P. et al. Major lipids, apolipoproteins, and risk of vascular disease. JAMA. 1993–2000; 2009: 302 Google Scholar , 3 Di Angelantonio E. Gao P. Pennells L. et al. Lipid-related markers and cardiovascular disease prediction. JAMA. 2012; 307: 2499-2506 Crossref PubMed Scopus (344) Google Scholar ]. Recent study shows that HDL dysfunctional may be present in ACS. And, HDL-C levels are decreasing with age [ [4] Ferrara A. Barrett-Connor E. Shan J. Total, LDL, and HDL cholesterol decrease with age in older men and women. The Rancho Bernardo Study 1984–1994. Circulation. 1997; 96: 37-43 Crossref PubMed Scopus (169) Google Scholar ]. Up to now, the effect of low HDL-C levels on the downstream prognostic in high-risk octogenarian patients with ACS has not been established. The purpose of the present study was to investigate the effect of plasma high-density lipoprotein cholesterol (HDL-C) on cardiovascular long-term outcomes in octogenarian patients with ACS.