Abstract
Histological studies have demonstrated an hexachlorophene induced change of the cerebral white matter in rats (Kimbrough). The following report is an ultrastructural description of the changes as seen in monkeys, with an attempt to explain the molecular mechanism by which the changes develop.A dose of 3 mg of hexachlorophene per kg was administered subcutaneously to four juvenile (3-4 yrs) monkeys (Macaca mulatta) twice daily for 3 months. At the end of the experiment four treated monkeys and two stock control monkeys were sacrificed under anesthesia. The head region was perfused with 2.5% glutaraldehyde in a modified Tyrode's solution and tissues were sampled from spinal cord, superior colliculus, thalamus-callosum, cerebellum and optic nerve, and prepared for electron microscopic examination.Light microscopic examination revealed the development of cystic spaces in the thalamus-callosum samples from all of the treated animals. Optic nerve and spinal cord samples also demonstrated cystic spaces, but not as extensively as in thalamus-callosum.
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