Abstract
In the course of studies on the production of isoagglutinins in human volunteers an agglutinin for sheep cells was encountered in the sera of a number of persons receiving group-specific A number of persons receiving group-specific A substance (Witebsky) and group-specific AB substance 9Witebsky).∗ Twenty-three student volunteers of Tufts College Medical School participated. Sixteen belonging to blood groups B and O received 0.17 to 1.0 mg of A substance in travenously. Blood samples were taken before injection and again 2 weeks after, Sheep cell agglutinins were studied by the method of Paul and Bunnell.1 An increase in titre of the second serum of 3 tubes or more above the titre of the first was observed in 7 volunteers, 9 remained unchanged or showed less definite increases. Seven volunteers belonging to blood group A received 0.05 mg of AB substance intravenously. Of these.Since A and AB substances are used to neutralize the isoagglutinins of O blood used for transfusion, the question arose of whether...
Published Version
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