Abstract
Studies on heterophile antibody response of rabbits to T. canis infection are reported. Rabbits showed normal heterophile serum antibody titres of 1 5 to 1 10 at the time of infection. Following initial infection with two doses of 1,200 T. canis infective eggs at an interval of two weeks between the doses, little change in the existing herterophile levels was observed. On reinfection with doses of 100,000 and 200,000 ova, a marked rise in heterophile antibody response was observed compared with that in rabbits which received these doses for the first time. In general the complement-fixing anti-Toxocara antibody response to reinfection showed somewhat similar trends to the heterophile antibody response. These heterophile antibodies resemble the classical Forssman type and the corresponding antigen has been shown to be present mainly in the infective eggs and in the intestine of the adult. The cuticle of the adult worm possessed little antigen of this type.
Published Version
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