Abstract
Ovarian cancer is one of the most malignant and aggressive tumors of the female reproductive system. Late diagnosis is one of the most significant problems: more than two-thirds of cases are detected only at stage III–IV. Ovarian cancer is characterized by a unique metastatic process. Implantation is the earliest and most common way of metastasis. It is often accompanied by fluid accumulation in the abdominal cavity, known as ascites. We report a case of low-grade serous ovarian carcinoma with a large heterogeneity of tumor cells in the ascitic fluid detected using multicolor flow cytometry. We demonstrated the advantages and benefits of this method in the diagnosis of ovarian cancer. Multicolor flow cytometry opens new horizons for liquid biopsy in oncology.
Highlights
Рак яичников (РЯ) – одна из наиболее злокачественных и агрессивно протекающих опухолей женской репродуктивной системы
Ovarian cancer is characterized by a unique metastatic process
We report a case of low-grade serous ovarian carcinoma with a large heterogeneity of tumor cells in the ascitic fluid detected using multicolor flow cytometry
Summary
Рак яичников (РЯ) – одна из наиболее злокачественных и агрессивно протекающих опухолей женской репродуктивной системы. В данном клиническом случае отражена большая гетерогенность опухолевых клеток в асцитической жидкости пациентки с low-grade серозной карциномой яичников, выявленной с помощью многоцветной проточной цитометрии. Ключевые слова: low-grade серозная карцинома яичников, асцитические опухолевые клетки, опухолевая гетерогенность, EpCAM, многоцветная проточная цитометрия, жидкостная биопсия
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