Abstract
Meeting abstracts The common γ-chain cytokine interleukin-15 (IL-15) regulates immune homeostasis and the fate of many lymphocyte subsets, and holds potential in fighting infections and cancer. We have previously showed that co-expression of IL-15 and IL-15 Receptor alpha (IL-15Rα) in the same
Highlights
The common g-chain cytokine interleukin-15 (IL-15) regulates immune homeostasis and the fate of many lymphocyte subsets, and holds potential in fighting infections and cancer
We have previously showed that co-expression of IL-15 and IL-15 Receptor alpha (IL-15Ra) in the same cell allows for efficient production and secretion of bioactive IL-15/IL-15Ra heterodimer, whereas singlechain IL-15 is unstable
IL-15 knock-out (KO) mice were used to evaluate the contribution of IL-15 in the regulation of general and vaccineinduced memory T cells
Summary
The common g-chain cytokine interleukin-15 (IL-15) regulates immune homeostasis and the fate of many lymphocyte subsets, and holds potential in fighting infections and cancer. Heterodimeric IL-15 regulates the differentiation and survival of different populations of memory T cells and the balance of effector and regulatory cells From Society for Immunotherapy of Cancer 28th Annual Meeting National Harbor, MD, USA.
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