Abstract
Introduction - Primary varicose veins (PVV) constitute an important both health and social problem. In developed countries their prevalence vary from 25 to 50% in women and from 7% to 40% in men and may lead to serious complications. To date, no specific cause for the development of varicose veins has been identified, even though a various environmental and genetic risk factors have been suggested to contribute to their formation. Epidemiological research highlighted a trend of familial clustering and associated increased risk of disease development.
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