Abstract
SummaryMuscles from three normal calves and three calves with hereditary muscular hypertrophy were biopsied at nine months of age and assayed histochemically for succinic dehydrogenase activity, and histologically for evidence of muscular degeneration. In addition, the biopsy samples were analyzed for total DNA, RNA, and protein. Blood samples from 13 normal and 12 hypertrophied animals were taken at 12 months of age and assayed for creatine phosphokinase activity. Histologically, no degenerative changes were detected in hypertrophied animals. No significant differences were found in concentrations of DNA, RNA, protein, or in serum creatine phosphokinase activity between normal and hypertrophied animals. There was a significant decrease in succinic dehydrogenase activity of the hypertrophied muscle. There were fewer reacting fibers, and the activity was less in those fibers from hypertrophied muscle which did react for succinic dehydrogenase. It is concluded that degeneration is not a part of this syndrom...
Published Version
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