Abstract
BackgroundHereditary angioedema (HAE) is a rare life-threatening disease that can occur in pregnancy. CaseA nulliparous woman was diagnosed as having HAE at 22 weeks of gestation after a series of symptomatic episodes. Following an initial course of C1 esterase inhibitor (C1EI) therapy for an acute episode of HAE, she was treated with danazol for prophylaxis. Danazol did not prevent recurrence of symptoms, and its use was discontinued after six weeks. Thereafter, the patient was treated exclusively with C1EI at weekly intervals for exacerbations of her HAE. At 37 weeks’ gestation, she delivered a healthy 3050 g female neonate. At the time of discharge the female neonate had no signs of virilization or congenital anomalies. ConclusionLow dose danazol was ineffective in treating this woman’s HAE in pregnancy. The use of C1EI in pregnancy is associated with good outcomes.
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