Herbaceutical approach for the Management of Obesity, Oxidative Stress using Pennisetum Glaucum by invitro and insilico Models

Abstract

Obesity is a condition in which there is excessive fat accumulation in adipose tissue, liver, skeletal muscle etc. It is a major concern for developing various disorders like type 2 diabetes, cardiovascular disease, hypertension, hyperlipidemia, atherosclerosis and cancer. In the present study, aqueous extract of Pennisetum glaucum seeds (AEPG) was screened for its anti-obesity and antioxidant activities by using in vitro models. Preliminary phytochemical analysis revealed the presence of flavonoids, tannins, phenols and carbohydrates. The pancreatic lipase inhibitory activity of the AEPG revealed its anti-obesity activity. Antioxidant activity of AEPG was performed by superoxide radical scavenging, hydrogen peroxide scavenging and hydroxyl radical scavenging activities, in which plant extract exhibited concentration dependent inhibitory action on respective free radicals. Pharmacokinetic studies i.e. in vitro ADME studies were also performed to components like Tricin, p-Coumaric acid and Syringic acid using Swiss ADME web tool. The ADME data of Tricin, p-Coumaric acid and Syringic acid suggest that these three molecules had good bioavailability score and which was further supported by their gastrointestinal absorption and good penetration power to the tissues. However further studies are required to establish its pharmacological actions in in vivo models and to isolate phytoconstituents that are actually responsible for antiobesity activity.