Abstract
Background:Human epidermal growth factor receptor 2 (HER2) plays an important role in the development and progression of breast cancer. To understand the precise association, this meta-analysis was conducted to estimate the association between HER2Ile655Val single nucleotide polymorphism (SNP) and susceptibility to early-onset breast cancer. Methods:A comprehensive database retrieval from PubMed, Embase, Web of Science and Google Scholar was pooled to investigate links between the HER2Ile655Val SNP and risk of breast cancer. Adjusted odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to appraise the association under the additive model (Ile vs. Val), dominant model (Val/Val + Ile/Val vs. Ile/Ile), and recessive model (Val/Val vs. Ile/Val + Ile/Ile). Results:Seventeen relevant studies with 11,749 cases and 8,105 controls were finally included. We found that HER2Ile655Val SNP is associated with an increased risk of breast cancer in an additive and dominant model. In the subgroup analysis with age stratification, a significant association between the HER2 codon 655 SNP and the risk of breast cancer was found in young women in an additive, dominant, and recessive model; conversely, no significant associations were indicated in older women. In the breast cancer subgroup, HER2Ile655Val SNP was significantly associated with younger age women with breast cancer in the dominant model. In contrast, no association between the HER2 codon 655 SNP and age was found in control populations. Conclusion:Our findings suggest that the Val allele in HER2 codon 655 SNP is strongly associated with breast cancer susceptibility in the young female population and is also significantly associated with younger age in women with breast cancer. HER2Ile655Val SNP might be a susceptibility factor that favours early-onset breast cancer.
Highlights
Breast cancer is the most common cancer among women, with an increasing incidence in most countries, representing a public health threat (Momenimovahed and Salehiniya, 2019; Zahmatkesh et al, 2016)
Several studies have independently discovered the association between HER2Ile655Val single nucleotide polymorphism (SNP) and different types of benign and malignant tumours, including breast cancer, prostate cancer, colorectal cancer, osteosarcoma, gastric cancer, uterine cervical carcinoma, and fibroadenoma
SNP is significantly correlated with six major types of cancer, suggesting that carriers of the Val allele and Val/Val genotype may be linked with an elevated risk of these cancers
Summary
Breast cancer is the most common cancer among women, with an increasing incidence in most countries, representing a public health threat (Momenimovahed and Salehiniya, 2019; Zahmatkesh et al, 2016). Breast cancer patients aged under 30 and 30-39 years were found to have a significantly lower survival rate than those aged 40-49 and 50-59 (Chen Hailong et al, 2016; Paluch-Shimon et al, 2020). Human epidermal growth factor receptor 2 (HER2), known as c-erbB2 and neu, is located on human chromosome 17q21 and is responsible for encoding a. Human epidermal growth factor receptor 2 (HER2) plays an important role in the development and progression of breast cancer. To understand the precise association, this meta-analysis was conducted to estimate the association between HER2Ile655Val single nucleotide polymorphism (SNP) and susceptibility to early-onset breast cancer
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