HER2 Amplification in Hydatidiform mole patients

Abstract

Hydatidiform mole is an abnormal pregnancy in which the placenta contains grape cell like vesicles (small sacs) , that are usually visible with the naked eye .Patients and methods : This study was carried out in Laboratories of College of Science, Wasit University , AL Zahraa and AL Karma Teaching Hospitals, from October 2014 to April 2015. The study included twenty Hydatidiform mole patients were taken randomly, and six non hydatidiform mole patients as control group. The patients with HM included 10 samples of complete H mole , and 10 samples of partial H mole. Chromogenic In Situ Hybridization (CISH) technique was used to detect the amplification of HER2 gene.Results: Regarding the HER2 amplification (over-expression of HER2) was significantly more frequent in H mole patients than in control (p≤0.05), also the same difference was indicated between complete H mole and control group. As well as between partial H mole and control group . While, HER2 amplification did not differ between complete H mole and partial H mole (p≤0.05) .