Abstract
1. 1. The association of ethanol and phenformin during 6 months in the Sprague-Dawley rat produces an alteration in lactate homeostasis. A basal blood lactate value of 54.13 ± 15.43 mg/dl was found compared to 23.65 ± 7.4 mg/dl in control rats. 2. 2. Lactic acid levels increased to 28.8 ± 7.42 mg/dl and 22.01 ± 8.08 mg/dl after chronic administration of ethanol or phenformin in Sprague-Dawley rats, respectively. Nevertheless, these were not statistically significant with respect to those of control group. 3. 3. The total hepatic collagen content after chronic administration of phenformin and ethanol was moderately elevated 7.12 ± 1.85 mg/g of wet tissue, and statistically significant with respect to the control group, 4.77 ± 1.17 mg/g. Collagen content values in phenformin and ethanol rats did not reveal statistically significant differences. 4. 4. Liver showed histological degenerative changes but not any sign of fibrosis after chronic administration of ethanol and phenformin together.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.