Hepatoprotective Effect of Vitamin-E (α-Tocopherol) on Trichloroethylene and Toluene Induce Liver Damage in Rats

Abstract

This study was design to investigate the harmful effect of trichloroethylene and toluene on the hepatic cell of rats and possible protective effect of vitamin-E (α-tocopherol) on these detrimental effects. This study aimed to evaluate organic solvents which are persistent and uninterrupted ecological pollutants that are capable to cause numerous dysfunctions in target tissues of exposed animal as well as humans. This study suggests that trichloroethylene (TCE) and toluene when administered in rats changes their metabolic disposition. Therefore, investigation work performed as to (a) Compare the rate of lipid peroxidation in hepatic tissues, (b). To study the concomitant effect on reduced glutathione in liver of rats subjected to TCE and toluene with vitamin-E (VE) to protect the damage of liver cells.