Abstract
<p class="Abstract">Search for medicinal plants to treat liver disorders is an important research topic on herbs. Acute toxicity study is a prerequisite for safety and dose fixation for further pharmacological actions. In the present study, aqueous and 95% ethanolic extract of whole plant of <em>Helicanthus elastica</em> were subjected to acute oral toxicity. The aqueous and ethanolic extract revealed no observable changes in the rats up to the dose level of 2,000 mg /kg body weight. The extracts were then screened for paracetamol-induced hepatic injury at dose levels of 200 and 400 mg/kg body weight (1/10 and 1/5 LD<sub>50 </sub>based on toxicity study). The aqueous extract of whole plant of <em>H. elastica</em> was found to produce significant (p&lt;0.05) reversal of the paracetamol-induced changes in the measured biochemical and histopathological parameters at lower dose of 200 mg/kg which was found to be better than ethanol extract at the same dose level.</p><p class="Abstract"><strong>Video Clip:</strong></p><p class="Abstract"><a href="https://www.youtube.com/v/cO6HI1Kikxs">Acute toxicity study and others:</a> 5 min 38 sec</p><p> </p>
Highlights
Mistletoes, the hemiparasites of Loranthaceae are medicinally important (Bussing, 2004)
The extracts were screened against paracetamol-induced hepatic injury at dose levels of 200 and 400 mg/kg body weight (1/10 and 1/5 LD50 based on toxicity study)
The ethanolic extract was concentrated over a water bath and aqueous extract was dried in freeze drier to obtain coffee brown residue
Summary
Mistletoes, the hemiparasites of Loranthaceae are medicinally important (Bussing, 2004). Many of these types of plants have not been studied scientifically though references are found in texts of Ayurveda and other folklore medicines. The plant is reported to have diuretic (Aleykutty et al, 1991; Jadhav et al, 2010), anti-tumour (Mary et al, 1994), antimicrobial (Sunil Kumar et al, 2014a), anti-oxidant (Sunil Kumar et al, 2014b) activities It is a source of many nutritional elements (Sunil Kumar et al, 2014c) and is found to contain friedelin, epifriedelinol, β-amyrin, β-sitosterol, ethyl gallate, gallic acid and β-sitosterol-3-β-D-glucopyranoside as major constituents (Sunil Kumar et al, 2015)
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