Abstract
Black cincau (<em>Mesona palustris</em> BL) or Grass black jelly is a traditional Indonesian food that has been used as a folk medicine and is effective against heat-shock, hypertension and diabetes. Therefore, the aim of this research was to determine the hepatoprotector effects of ethanol extracts of black cincau in protecting the liver induced by high doses of paracetamol. The ethanol extracts of black cincau were studied for their hepatoprotective and antioxidant effects on paracetamol (750 mg/kg BW) induced acute liver damage on Wistar rats and treatment during 4 weeks. The degree of protection was measured by using biochemical parameters such as Serum Glutamate Oxalate Transaminase (SGOT) and Serum Glutamate Pyruvate Transaminase (SGPT) and Alkaline Phosphatase (ALP) were estimated. The result showed that ethanol extracts of black cincau IC<sub>50</sub> value of 46.92 ppm and 829.7 ppm for total phenols. The ethanol extracts of black cincau at a dose level of 500 and 1000 mg/kg BW produce significant (p<0.05) hepatoprotection by decreasing the activity of SGOT, SGPT and ALP). From this study, it can be concluded that the ethanol extracts of black cincau is not only an effective hepatoprotective agent, but also possesses significant (p<0.05) antioxidant activity.
Highlights
Liver disease is still a worldwide health problem
Black cincau (Mesona palustris BL) or Grass black jelly is a traditional Indonesian food that has been used as a folk medicine and is effective against heat-shock, hypertension and diabetes
We found that phenolic compounds extracted from hsian-tsao and black cincau significantly contributed to the antioxidant activity and free radical scavenging effects (Yen and Hung, 2001; Widyaningsih, 2010)
Summary
Liver disease is still a worldwide health problem. conventional or synthetic drugs used in the treatment of liver diseases are inadequate and sometimes can have serious side effects. Black cincau (Mesona palustris BL) or Grass black jelly is a traditional Indonesian food that has been used as a folk medicine and is effective against heat-shock, hypertension and diabetes. Hsian-tsao is used as a herbal remedy in the folk medicine of China and is effective against heat-shock, hypertension, diabetes, liver disease and muscle and joint pains. Many compounds, such as sterol compounds, stigmasterol, â-sitosterol, tripterpene compounds, oleanolic acid and ursolic acid, have been isolated from Hsian-tsao (Hung and Yen, 2001). The objective of this study was to hepatoprotective effect of ethanolic extract of Black cincau (Mesona palustris BL) on paracetamol-induced liver toxicity in rats
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