Abstract
Antioxidant and Hepatoprotective Effects of Dried Flower Extracts of Hibiscus sabdariffa L. on Rats Treated with Carbon TetrachlorideItoro F Usoh, Itemobong S Ekaidem, Oboso E Etim, Henry D Akpan, Enomfon J Akpan, A Fakoya
Highlights
Exposure to carbon tetrachloride (CCl4), a well-known hepatotoxin, is known to induce oxidative stress and causes liver injury by the formation of free radicals
This study was aimed at investigating the protective effect of aqueous extract of the leaves of Solanum macrocarpon against CCl4-induced liver damage in rats
Group 1 served as control, groups 2, 3 and 4 animals were pre-treated with leaf extract of Solanum macrocarpon at 250mg/kg, 500mg/kg and 750mg/kg body weight respectively for 14 days prior to a single intraperitoneal administration of CCl4
Summary
Exposure to carbon tetrachloride (CCl4), a well-known hepatotoxin, is known to induce oxidative stress and causes liver injury by the formation of free radicals. Free radical-induced lipid peroxidation is one of the major causes of cell membrane damage which leads to a number of pathological conditions (Slater, 1984; Oberley, 1988; Halliwell, 1993). Studies showed that various plant extracts could has the potential to protect organs against CCl4 - induced oxidative stress by altering the levels of increased lipid peroxidation as well as enhancing the decreased activities of antioxidant enzymes (Rajesh and Latha, 2004). Solanum macrocarpon is an important medicinal plant with rich source of nutritional and medicinal constituents. It is widely cultivated in West Africa where it Adewale et al / Journal of Applied Pharmaceutical Science 5 (Suppl 2); 2015: 081-086
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