Abstract
Background:Literature reports numerous causes for liver damage, which mainly include viral hepatitis (most commonly hepatitis B), cirrhosis, cell stress, hepatic damage by NSAIDs or alcohol. In the present study, methanolic extracts ofTectona grandisleaves were evaluated for hepatoprotective activity against CCl4induced liver damage in rats.Methods:Hepatic injury in rats was carried out using the CCl4-induced hepatotoxic model. Methanolic extracts ofTectona grandiswere administered orally at two different doses (200mg/kg & 400mg/kg) daily. The biochemical parameters (SGOT, SGPT, ALP, and serum bilirubin) were estimated using Reitman and Frankel's method in addition Kind King’s method.Results:The preliminary phytochemical studies confirmed the existence of saponins, carbohydrates, tannins, and flavonoids. CCl4treated group boost the concentrations of Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), Alkaline Phosphate (ALP) and serum bilirubin as compared to control group (rats treated with vehicle). The methanolic extract of plant (200 mg/kg & 400 mg/kg) and standard drug silymarin (100 mg/kg) produced a significant decrease in raised levels of these enzymes as compared to control.Conclusion:The results clearly indicate thatTectona grandisleaves have notable hepatoprotective activity in rats hepatic damage induced by CCl4.
Highlights
The liver is a large, solid, gland situated in the right upper quadrant of the abdominal cavity
Many reasons were reported in the literature for liver damage i.e. hepatitis B, cirrhosis and hepatic damage caused by drugs like NSAIDs or ex
Phytochemical screening shows the presence of steroids, phenolic components, tannins, flavanoids and saponin in methanolic extracts of Tectona grandis leaves
Summary
The liver is a large, solid, gland situated in the right upper quadrant of the abdominal cavity. It is the chief organ of the body that metabolizes carbohydrate, lipid, protein, processing of drugs and hormones. Many reasons were reported in the literature for liver damage i.e. hepatitis B (viral hepatitis), cirrhosis and hepatic damage caused by drugs like NSAIDs (acetaminophen) or ex-. MPT is caused by direct cell stress through intrinsic pathway [2]. Activation of pro-apoptotic proteins and intracellular stress on cascades is involved in the intrinsic pathway. Literature reports numerous causes for liver damage, which mainly include viral hepatitis (most commonly hepatitis B), cirrhosis, cell stress, hepatic damage by NSAIDs or alcohol. Methanolic extracts of Tectona grandis leaves were evaluated for hepatoprotective activity against CCl4 induced liver damage in rats
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
