Hepatoprotective Activity Of Some Quercetin Derivatives

Abstract

The study was designed to evaluate the hepatoprotective activity of some quercetin derivatives 6-Bromoquercetin (Comp 1), 6,8-Dibromoquercetin (Comp 2), 2',5',6,8-Tetrabromoquercetin (Comp 3) and ,5',6,6',8-Pentabromoquercetin (Comp 4) in acute experimental liver injury induced by carbon tetrachloride and paracetamol. The effects observed were compared with a known hepatoprotective agent, silymarin. Four quercetin derivative was prepared by bromination, 6-Bromoquercetin (Comp 1), 6,8Dibromoquercetin (Comp 2), 2',5',6,8-Tetrabromoquercetin (Comp 3) and ,5',6,6',8-Pentabromoquercetin (Comp 4) respectively. In the acute liver damage induced by different hepatotoxins, quercetin derivatives 6-Bromoquercetin (Comp 1) and 6,8Dibromoquercetin (Comp 2) significantly reduced the elevated serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and bilirubin whereas other quercetin derivatives 2',5',6,8-Tetrabromoquercetin (Comp 3) and 2',5',6,6',8-Pentabromoquercetin (Comp 4) did not show significant reduction in elevated serum levels when compared to standard silymarin (100mg/kg body weight). Histological examination of the liver tissues supported the hepatoprotection. It is concluded that the quercetin derivatives possesses good hepatoprotective activity.