Abstract
Traditionally Viola odorata is used for liver protection. To provide scientific support to its traditional use, aqueous methanolic extract of V. odorata (250 mg/kg and 500 mg/kg) was given to mice intoxicated with paracetamol. Obtained results demonstrated that the extract significantly (p<0.01-0.001) reduced paracetamol induced increase levels of serum hepatic enzymes and total bilirubin. Histopathological studies showed that the plant attenuated the hepatocellular necrosis and inflammation. HPLC results showed the presence of hepatoprotective flavonoids (isorhamnetin and luteolin) in the extract. It was concluded from the present study that V. odorata has hepatoprotective activity against paracetamol-induced liver injury in mice.
Highlights
Now-a-days, liver diseases are one of the major issues of all the medical community due to the higher rate of mortality and morbidity
Paracetamol administration caused damage to hepatocytes demonstrated by raised level of liver enzymes (ALT, AST and ALP) and total bilirubin as compared to control
Elevated levels of these enzymes are indicative of cellular damage and loss of functional integrity of hepatocytes
Summary
Now-a-days, liver diseases are one of the major issues of all the medical community due to the higher rate of mortality and morbidity. There are lot of medicines and natural plants available in commercial market for liver diseases. These products do not cure all the liver symptoms. Flavonoids have been identified in V. odorata (Siddiqi et al, 2012) and they may have hepatoprotective activity (Ali et al, 2013). Phytochemical profile and traditional use of V. odorata in liver injury appealed us to scientifically evaluate its hepatoprotective potential
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