Abstract
Morus nigra (Family Moraceae) is traditionally used injaundice, diabetes, hypertension, cough, fever and cancer. The current study was conducted to determine hepatoprotective activity of aqueous methanolic extract of leaves of M. nigra . Two doses of 250 mg/kg p.o and 500 mg/kg p.o showed that extract of M. nigra produced significant (p<0.001) reduction in liver enzymes (ALT, AST, ALP) and total bilirubin induced by paracetamol and the results are comparable to silymarin (p<0.001). Results were supported by histopathologi-cal investigations, phytochemical screening and detection of active consti-tuents by HPLC. The current study showed that aqueous methanolic extract of M. nigra possess hepatoprotective activity that might be due to quercetin, luteolin and isorhamnetin. It was concluded from this study that M. nigra has hepatoprotective activity against paracetamol induced liver injury in mice. DOI: http://dx.doi.org/10.3329/bjp.v9i1.17337 Bangladesh J Pharmacol 2014; 9: 60-66
Highlights
The problem of resistance and tolerance to the existing drugs has created a decreased efficacy of these drugs in use
After administration of 250 and 500 mg/kg of aqueous methanolic extract of M. nigrathe mean ALT values were observed as 50.6 ± 7.2 IU/L (p
The normal mean value of AST 36.5 ± 3.6 IU/L was elevated to 101.2 ± 9.2 IU/L with paracetamol ingestion which was reduced to 41.8 ± 5.0 IU/L (p
Summary
The problem of resistance and tolerance to the existing drugs has created a decreased efficacy of these drugs in use. This problem has been tried to be overcome by increasing the drug delivery to the target site by the use of polymers (Khalid et al, 2009; Hussain et al, 2011) or through nanotechnology (Naz et al, 2012; Ehsan et al, 2012), synthesis of new drugs, either by the use of proteomics (Qadir, 2011), or synthesis from lactic acid bacteria (Masood et al, 2011), or marine microorganisms (Javed et al, 2011). Morus nigra (Moraceae) widely distributed in Asia, Africa, Europe, and America. It is commonly as Black Mulberry (English) and Shah-toot (Hindi/Urdu). It has been reported that M. nigra is antioxidant (Ozgenet al., 2009), anti-nociceptive (Padilhaet al., 2009), anti-inflammatory (Padilhaet al., 2010), antidiabetic (Husseinzadehet al., 1999), antibacterial (Mazimbaet al., 2011), cardiac depressant (Malik et al, 2012), effective for maternal health (Volpetoet al., 2011), vermifuge and anti-cancer (Kumar and Chauhan, 2008)
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