Hepato-Protective Activities of Ethanol Extracts of African Eggplant and Bitter Leaf in Alloxan Induced Diabetic Rats

Abstract

Diabetes is a metabolic disorder, which affect all system of the body including the liver. This study focused on the effect of the ethanol extract of African eggplant and bitter leaf and their combination on the liver structure, antioxidant enzymes activities and biochemical parameters in the liver of alloxan induced diabetic rats. Twenty-five male wistar rats were grouped into normal control group A, diabetic control group B, 100 mg/kg African eggplant extract treated group C, 100 mg/kg bitter leaf extract treated group D and combination of 100 mg/kg of African eggplant and 100 mg/kg bitter leaf treated group E. The results study showed that group E rats showed significant reduction in the activity of AST, ALP and AST. In the antioxidant enzyme activity, the administered extracts increased the antioxidant enzyme activities and reduced lipid peroxidation, thereby protecting the cells from oxidative stress. The micro- histo-architecture of the liver showed improvement and regenerative changes across the treated groups. The study reveal that combination of the ethanol leaf extract of bitter leaf and African eggplant can manage liver malfunction caused by diabetes.