Abstract
The hepatoprotective actions of nine compounds isolated from the leaves of Clausena lansium (Loor.) Skeels, Rutaceae were studied. The nine compounds at the dose of 250 mg/kg, except demethylsecoclausenamide, significantly depressed the elevated serum transaminase in mice intoxicated with CCl4. Further study on the more abundant components, seco-clausenamide and clausenamide, demonstrated that both compounds decreased the hepatotoxicity of thioacetamide and acetaminophen in mice. Clausenamide was shown to significantly inhibit CCl4-induced lipid peroxidation of liver microsomes and 14C-CCl4 covalent binding to microsomal lipids. The results indicate that eight compounds isolated from Clausena lansium have hepatoprotective activity in mice. Drug Dev. Res. 39:174–178. © 1997 Wiley-Liss, Inc.
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