Hepato-nephro-toxicity Induced by Premium Fungicide and Protective Effect of Sesame Oil

Abstract

Background: Fungicides impact on agriculture is reflected by the wide spread use of azoxustrobin (AZX) and metalxyl M, the active ingredients of premium fungicide used on more than 80 different crops. Objective: The present study aimed to investigate the hepato-renal-toxicity of premium fungicide on adult albino rats and focused on benefits of sesame oil in detoxification of toxicological effects of fungicides. Materials and methods: Thirty male albino rats allocated into five groups, -ve, +ve control and sesame oil groups. While the two other groups were treated with sesame oil before and after fungicide exposure daily by gavage for (28 days). Results: Exposure of male albino rats to Azoxystrobin fungicide resulted in liver and kidney injury as evidenced by increased liver and renal function bioindicator (ALT, AST, ALP, urea and creatinine)..Also, glutathione (GSH) was significantly decreases and malondialdhyde (MDA) was increased as oxidative stress biomarkers. In addition, degeneration of some tubular epithelial cells and hemorrhage in kidney and severe inflammatory cell infiltration in liver. Conclusion: The present study concluded that premium had induced functional and histological changes in liver and kidney male rats. Sesame oil successfully ameliorated the oxidative stress, hepatotoxicity and nephrotoxicity of fungicide.