Abstract
We report a patient with chronic virus B and C hepatitis, who developed a fatal hepatic failure after chemotherapy suppression. A 56 years old man diagnosed of glioblastoma in treatment with cisplatin, procarbacin and UFT whose treatment was stopped because a raise in serum transaminases. Five days later, he developed an acute hepatic failure and died.Fulminant hepatitis is a known complication of immunosuppresive therapy withdrawal in patients with chronic virus B and virus C infection. It is accepted to be caused by the reactivation of viral replication during inmunosupressive therapy followed by hepatic necrosis with the restablishment of normal immunity.Management should include corticosteroid therapy and probably lamivudine, however the best way to face it is to prevent it measuring the viral DNA in patients with chronic hepatitis receiving chemotherapy.
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