Abstract
BackgroundHepatitis C virus (HCV) is one of the leading causes of viral hepatitis worldwide and its genotype 3a is predominant in vast areas of Pakistan.FindingsThe present study reports the first full sequence of HCV 3a isolate PK-1 from Pakistan. This nucleotide sequence was compared with six other HCV genotype 3a full length sequences from different regions of the world by using statistical methods of phylogenetic analysis.ConclusionThe nucleotide difference of these seven sequences shows that HCV genotype 3a of phylogenetically distinct origin is circulating in Pakistan.
Highlights
Hepatitis C virus (HCV) is one of the leading causes of viral hepatitis worldwide and its genotype 3a is predominant in vast areas of Pakistan
HCV subtype 3a is the most common genotype circulating in India [9], Nepal [10] and Pakistan [11]
Genetic analysis of HCV genotype 3a is very important as it is very sensitive to interferon therapy compared to the other genotypes
Summary
Hepatitis C virus (HCV) is one of the leading causes of viral hepatitis worldwide and its genotype 3a is predominant in vast areas of Pakistan. Findings Hepatitis C virus (HCV) is leading cause of chronic liver disease [1] with estimated 170-200 million infected persons worldwide [2] including approximately 17 million in Pakistan [3]. HCV subtype 3a is the most common genotype circulating in India [9], Nepal [10] and Pakistan [11]. Genetic analysis of HCV genotype 3a is very important as it is very sensitive to interferon therapy compared to the other genotypes.
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