Hepatitis C seroprevalence among people living with HIV/AIDS and pregnant women in four provinces in Cambodia: an integrated bio-behavioral survey

Phearavin Pheng,Vonthanak Saphonn,Phalla Chea,Laurence Meyer,Sovannary Tuot,Olivier Ségéral,Siyan Yi,John M Kaldor

doi:10.1186/s12879-022-07163-2

Abstract

BackgroundUnderstanding the extent of viral hepatitis burden in specific subgroups, such as pregnant women and people living with HIV/AIDS (PLWHA), and their geographic distribution is essential for evidence-informed policy and mobilizing resources for targeted treatment and prevention efforts. However, in Cambodia, the epidemiology of hepatitis C remains uncertain. We estimated the hepatitis C virus (HCV) burden and transmission risk factors among PLWHA and pregnant women attending antenatal care (ANC) in Cambodia.MethodsBetween March and April 2016, we conducted a cross-sectional survey in four diverse geographical areas: the capital city of Phnom Penh and three provinces. We collected information on demographic characteristics and risk behaviors and performed HCV antibody (Anti-HCV) testing among pregnant women attending public ANC clinics and among those receiving HIV care at the hospitals. We computed the prevalence of HCV among the two population subsets and performed logistic regression analyses to identify risk factors associated with HCV antibody positivity.ResultsOf 935 participants enrolled, 510 (54.6%) were pregnant women and 425 (45.4%) were PLWHA. Anti-HCV prevalence was significantly higher in PLWHA than in pregnant women (29/425, 6.8% vs 5/510, 0.9%, P < 0.001). Of the geographic regions, Preah Sihanouk province (Southwest) had the highest anti-HCV prevalence among PLWHA (12.0%, P = 0.031). There was no significant geographic difference in anti-HCV prevalence among pregnant women. In multivariable analyses (data subset to PLWHA), HCV infection was significantly associated with having a family member positive for HCV (OR = 7.6 [95% CI: 1.01–57.84], P = 0.048) and a history of intravenous medication injection in the last 5 years (OR = 7.1 [95% CI: 2.79–18.10], P < 0.001).ConclusionsHCV infection is relatively common among Cambodian PLWHA, likely related to intravenous medication injection and intra-familial viral transmission. Systematic HCV testing and care among PLWHA (and possibly their family members) might be necessary. Setting up a surveillance system for HCV might also be beneficial for some geographical regions and populations.

Highlights

Understanding the extent of viral hepatitis burden in specific subgroups, such as pregnant women and people living with Human immuno-deficiency virus (HIV)/AIDS (PLWHA), and their geographic distribution is essential for evidence-informed policy and mobilizing resources for targeted treatment and prevention efforts
Knowledge/attitudes on hepatitis C prevention and care Participants indicated high levels of willingness to get tested for hepatitis C virus (HCV) and to go for further investigations or treatment if HCV test positive
Correct answers to questions about whether blood should be screened for hepatitis C before transfusion, and barbers should use new blades or safe equipment for ear and nose piecing were reported by more than 90% of participants in both groups (Table 2)

Summary

Introduction

Understanding the extent of viral hepatitis burden in specific subgroups, such as pregnant women and people living with HIV/AIDS (PLWHA), and their geographic distribution is essential for evidence-informed policy and mobilizing resources for targeted treatment and prevention efforts. We estimated the hepatitis C virus (HCV) burden and transmission risk factors among PLWHA and pregnant women attending antenatal care (ANC) in Cambodia. The World Health Organization (WHO) Global Health Sector Strategy for Viral Hepatitis calls for the elimination of viral hepatitis by 2030, aiming at a 90% reduction in incidence and a 65% reduction in mortality. To reach this target, 90% of chronic hepatitis cases need to be diagnosed, and 80% of eligible cases treated [1]. Serological surveys can improve the understanding of the distribution of HCV infection in the general population and identify specific high-risk groups

Methods

Results

Discussion

Conclusion