Hepatitis B Surface Antigen (HBsAg) Seroprevalence in a Senegalese “Prevent Mother-to-Child Transmission of HIV” Cohort

Abstract

Introduction Senegal is classified by WHO among the countries where the prevalence of HBV is high To better address the management and prevention in both HBV infected and uninfected patients in decentralized areas of Senegal we investigated the prevalence of chronic hepatitis B infection in a Prevent Mother to Child Transmission of HIV PMTCT for Dried Bloot Spots in Senegal Objective The objective of our work is to find the frequency of hepatitis B infection in both HIV positive and ndash negative patients from a PMTCT cohort From Dried Blood spot in Senegal Materials and Methods We analyzed patients from a PMTCT cohort among whom were HIV positive were HIV negative and was questionable HIV positive The samples were was submitted to the test kit Determine HBsAg the ELISA kit Microscreen HBsAg and HBsAg ELISA Qualitative Architect II kit for the detection of HBsAg Result The average age was weeks and the sex ratio was M F Patients were predominantly male with The overall frequency of HBsAg was in HIV patients and in HIV negative the highest prevalence was in HIV negative patient rsquo s under weeks which was The second highest prevalence was in HIV negative patients weeks with positive for HBsAg followed by prevalence rate in patients weeks In the group of HIV negative patients HBsAg was more prevalent among women than in men Table In addition the overall analysis of HIV prophylactic status showed that the majority of the mothers used the combination AZT TC NVP Finally HIV negative patients are more likely exposed to HBV infection Conclusion The incidence of hepatitis B is high in children not infected with HIV with the prophylactic status of mothers showing a majority use of the combination AZT TC NVP Finally HIV negative patients are more likely exposed to HBV infection