Abstract
Aims: To analyze the effects of exercise performed at the aerobic/anaerobic transition (Lan) on Non-Alcoholic Hepatic Steatosis (NAHS) markers in type 1 diabetic rats. Methods: Adult Wistar rats were separated into four groups: Sedentary Control (SC), Trained Control (TC), Sedentary Diabetic (SD) and Trained Diabetic (TD). The trained groups swam supporting workloads equivalent to the Lan for one hour/day, five days/week, for eight weeks. Body weight, serum albumin concentrations, glucose concentrations, Free Fatty Acid (FFA) concentrations, NAHS markers (Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) and total lipid concentrations in the liver were analyzed. Results: The diabetic groups showed higher serum glucose concentrations and more weight loss compared to the controls, although the TD group was less affected than the SD group. Training resulted in a decrease in serum glucose levels in the diabetic rats. The NAHS markers, total lipid concentrations in the liver and serum albumin concentrations did not differ between the groups. However, the diabetic animals had higher serum FFA levels than the controls. Conclusion: Physical training at Lan attenuates weight loss and improves serum glucose homeostasis in diabetic animals. In addition, serum ALT and AST enzymes proved to be adequate markers of lipid levels in the livers in this animal model.
Highlights
Diabetes Mellitus (DM) results from a reduction in either the secretion or the action of insulin and causes impairment in both glucose storage and glucose use by cells
The serum glucose concentrations of the diabetic animals were increased compared to the controls and a significant decrease was observed in the Trained Group (TD) when compared to the Sedentary Group (SD) (Table 1)
Serum albumin concentrations did not differ between the groups (Table 1)
Summary
Diabetes Mellitus (DM) results from a reduction in either the secretion or the action of insulin and causes impairment in both glucose storage and glucose use by cells. Type 1 Diabetes Mellitus (DM1) can result in serious complications that reduce both quality of life and life expectancy [2]. These complications include retinopathy, renal disease, atherosclerotic macrovascular disease, debilitating neuropathies and hepatic diseases, such as Hepatic Steatosis (HS). Non-Alcoholic Hepatic Steatosis (NAHS) is one of the most common causes of chronic hepatic diseases, followed by hepatitis C and alcoholic HS
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