Hepatic hemodynamics and oxygen metabolism during hepatic artery occlusion and reperfusion: effects of dobutamine and inhalation of 100% oxygen.

Abstract

Hepatic hemodynamics, oxygen metabolism, and lactate metabolism during hepatic artery occlusion and reperfusion with and without supplemental oxygen and dobutamine (DOB) were studied in dogs. After a 60-min occlusion, hepatic arterial blood flow recovered about 80% of the preocclusion values after 10 min of reperfusion. However, portal vein blood flow gradually decreased during both occlusion and reperfusion. The partial pressure of oxygen in the portal vein blood (PPVO2) did not change significantly during the experiment. Accordingly, hepatic oxygen (HO2) delivery and consumption (HVO2) decreased markedly during occlusion and did not recover completely after 60 min of reperfusion. Although inhalation of 100% oxygen did not affect hepatic hemodynamics, it markedly increased PPVO2. DOB did not effectively increase PPVO2 though it increased portal vein flow (PVF). Both inhalation of 100% oxygen and DOB infusion enhanced HO2 delivery and HVO2 during hepatic artery occlusion and reperfusion. The hepatic lactate uptake was limited in the control group, however, it was improved by 100% oxygen and, especially, DOB both during occlusion and reperfusion. These data support the conclusion that inhalation of 100% oxygen and DOB administration effectively support hepatic function during hepatic artery occlusion.