Hepatic Failure-induced Hypogonadism in a Prostate Cancer Patient

Abstract

Hypogonadism owing to systemic diseases in prostate cancer is rare. Here, we present a patient with metastatic prostate cancer to the pericardium who had low serum testosterone level due to hepatic failure. The patient had cardiac tamponade, and pericardiocentesis revealed sanguineous exudate. Cytology revealed adenocarcinoma. High serum prostate-specific antigen level of 244 ng/mL was detected. The patient experienced complications of stress gastric and duodenal ulcer perforation and underwent subtotal gastrectomy. Perioperative intra-abdominal inflammatory process caused subsequent cholestasis and hepatic dysfunction. Transrectal ultrasound-guided prostate biopsy confirmed prostate cancer. Hypogonadism and a gradual decline in prostate-specific antigen were detected without any hormone therapy. The patient died due to hepatic failure in the 12(th) postoperative week.